Background: In this article, we examined the relationship between the pre- and postoperative brain natriuretic peptide (BNP) levels and pre-, intra-, and postoperative hemodynamic parameters in patients undergoing coronary artery bypass grafting (CABG) and combined CABG and valve operations.

Methods: Thirty patients with II and III ASA enrolled in the study were divided into two groups, each with 15 patients: CABG surgery (Group 1, 13 males, 2 females; mean age 62.2±8.6 years) and CABG + valve replacement surgery (Group 2, 13 males, 2 females; mean age 64.1±10.6 years). Patient data were prospectively collected. Anesthetic induction and endotracheal intubation were performed with 10 μg/kg fentanyl and 0.1-0.2 mg/kg etomidate, and 0.15 mg/kg cisatracurium. Isoflurane 1%, cisatracurium 0.1 mg/kg/hr infusion and 0.15 μg/kg/min fentanyl was used for anesthetic maintenance. Systemic and pulmonary arterial pressures were monitored. NT-proBNP levels and troponin T and CK-MB levels were recorded at pre- and postoperative 4th and 12th hours in both groups.

Results: Demographic and hemodynamic data were not significantly different between the two groups. In both groups, NT-proBNP values increased to peak levels at 24 hours postoperatively, however it was not associated with hemodynamic parameters and inotropic support.

Conclusion: There was no statistical difference between NT-proBNP levels in both groups preoperatively. Postoperative NT-proBNP levels were higher in group 2 (longer cross-clamp, and cardiopulmonary bypass time) at the 4th and 12th hours. However the duration in hospital and in the intensive care unit were longer in group 1 patients with high preoperative NT pro-BNP levels.

Keywords : Brain natriuretic peptide; coronary artery bypass grafting; endocrine system