ISSN : 1301-5680
e-ISSN : 2149-8156
TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effects of chlorhexidine gluconate and silver nitrate on rabbit lung: an experimental study
Ekber Şahin1, Şahande Elagöz2, Burçin Çelik1, Aydın Nadir1, Şule Karadayı3, Yücel Akkaş1, Melih Kaptanoğlu1, Şinasi Manduz4
1Departments of Thoracic Surgery, Medicine Faculty of Cumhuriyet University, Sivas
2Departments of Pathology, Medicine Faculty of Cumhuriyet University, Sivas
3Departments of Emergency, Medicine Faculty of Cumhuriyet University, Sivas
4Departments of Cardivascular Surgery, Medicine Faculty of Cumhuriyet University, Sivas
Background: In this study, we investigated the effects of chlorhexidine gluconate and silver nitrate on the lungs and determine their utility in operations for pulmonary hydatid cysts.

Methods: Thirty New Zealand Wistar albino rabbits weighing between 2750 and 3000 grams were used in the study and divided into three groups. In the first (control) group, normal saline (0.09% NaCl); in the second group, silver nitrate (0.5%); and in the third group, chlorhexidine gluconate (0.04%) was administered intrathraceally. Thirty days after the procedure, the tracheobronchial and parenchymal changes in the subjects were evaluated histopathologically. Tracheobronchial changes were evaluated with respect to tracheal pathology whereas peribronchial lymphocytic infiltration and parenchymal changes were evaluated with respect to interstitial lymphocytic infiltration, hemorrhage-edema, fibrosis and pneumonitis.

Results: The rate of interstitial lymphocytic infiltration was higher in the chlorhexidine gluconate group than in the control group, and the rates of fibrosis and fibrin accumulation were higher in the silver nitrate group than in the control group. No statistically significant differences in other parameters were found between the groups.

Conclusion: The results of the study indicate that chlorhexidine gluconate (0.04%) has minimal negative effects on the rabbit lung and tracheobronchial mucosa and is a more reliable agent than silver nitrate.

Keywords : Chlorhexidine gluconate; hydatid cyst; pulmonary; silver nitrate
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