ISSN : 1301-5680
e-ISSN : 2149-8156
TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
EFFECT OF ASPARTATE-GLUTAMATE ENRICHED BLOOD CARDIOPLEGIA ON LEFT VENTRICULAR FUNCTIONS: ASSESMENT WITH NITRIC OXYDE LEVELS
Berent DİŞÇİGİL, M. İsmail BADAK, Mehmet BOĞA, Uğur GÜRCÜN, *Fatih İSLAMOĞLU, *Erdem ÖZKISACIK, *Suat BUKET, *Ali TELLİ, *Tamer BAKALIM
Adnan Menderes Üniversitesi Tıp Fakültesi, Kalp Damar Cerrahisi Anabilim Dalı, AYDIN
*Ege Üniversitesi Tıp Fakültesi, Kalp Damar Cerrahisi Anabilim Dalı, İZMİR
The effect of aspartate and glutamate enriched blood cardioplegia on myocardial nitric oxide production and left ventricular function was assessed on twenty patients undergoing elective coronary artery bypass grafing. Routine blood cardioplegia was used in 10 patients (control group), glutamate and aspartate enriched blood cardioplegia was in the other 10 (study group). Cardioplegia was introduced antegradely and blood samples were collected through coronary sinus catheter for nitric oxide (NO) and enzyme levels. Hemodynamic measurements were done before and following cardiopulmonary bypass (CPB). The mean age was 61.3 ± 2.1 and 57.6 ± 2.4 years in the study and control group, respectively. The number of distal anastomosis, cross-clamp and times were similar between the two groups. Although NO leels were found to be higher in the study group, it did not reach statistical significance. There was no statistical difference in enzyme levels between the two groups, as well. However, hemodynamic measurements showed better left ventricular function in the study group (p < 0.05).

In conclusion, glutamate and aspartate enriched blood cardioplegia may be an alternative method for myocardial protection in patients with left ventricular dysfunction, in reoperations and in cardiac repairs necessitating longer aortic cross-clamp times.
Key words: Aspartate and glutamate, nitric oxide, left ventricular function.

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