Pretreatment with carnosol in lung ischemia reperfusion-induced renal injury

Burhan Apilioğulları; Recep Keşli; Hıdır Esme; Ali Yüceaktaş; Banu Yoldaş

doi:10.5606/tgkdc.dergisi.2014.9362

Burhan Apilioğulları¹, Recep Keşli², Hıdır Esme³, Ali Yüceaktaş⁴, Banu Yoldaş³

Department of Thoracic Surgery, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
¹Department of Thoracic Surgery, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
²Departments of Medical Microbiology, Konya Training and Research Hospital, Konya, Turkey
³Departments of Thoracic Surgery Konya Training and Research Hospital, Konya, Turkey
⁴Departments of Anesthesiology and Reanimation, Konya Training and Research Hospital, Konya, Turkey

DOI : 10.5606/tgkdc.dergisi.2014.9362

Background: This experimental study aims to investigate the protective effects of carnosol on kidney injury induced by lung ischemia/reperfusion (I/R).

Methods: Twenty-four New Zealand white rabbits were randomized into three groups. Group IR; lung I/R group (60 min ischemia-60 min reperfusion), group CIR; bolus injection of carnosol before lung I/R, and group S; sham group (pulmonary hilum was not clamped). Renal tissue myeloperoxidase (MPO) and intercellular adhesion molecule-1 (ICAM-1) levels were evaluated.

Results: Renal tissue MPO and ICAM-1 levels were significantly higher in the group IR compared to the group CIR and group S (p=0.021 and p=0.0001 respectively). No statistically significant difference in the parameters evaluated was detected between the group CIR and the group S.

Conclusion: Our study result suggests that lung I/R injury causes increased renal tissue MPO and ICAM-1 levels, which are related to activated neutrophil sequestration and carnosol may play a protective role against this kidney injury.

Keywords : Carnosol; ischemia reperfusion; lung; renal injury

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