ISSN : 1301-5680
e-ISSN : 2149-8156
TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
Are patients, who were previously diagnosed with coronary artery disease by coronary angiography, on optimal medical treatment?
Ahmet Temiz1, Ali Ümit Yener2, Ahmet Barutçu1, Emine Gazi1, Burak Altun1, Adem Bekler1, Ahmet Vural3, Turgut Özkan2, Tolga Kurt2, Gökhan Erbağ4, Hacer Şen4
1Departments of Cardiology, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey
2Departments of Cardiovascular Surgery, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey
3Departments of Microbiology, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey
4Departments of Internal Medicine, Medical Faculty of Çanakkale Onsekiz Mart University, Çanakkale, Turkey
DOI : 10.5606/tgkdc.dergisi.2015.10448
Background: This study aims to detect the drug usage rate of patients who had coronary artery disease (CAD) diagnosis by coronary angiogram (CAG).

Methods: Reports of 1,549 patients (993 males, 556 females; mean age 62.9±10.9 years; range 20 to 87 years) (184 normal CAG, 1,365 CAD) who were performed CAG between October 2009 and February 2012 were retrospectively analyzed. Medication data were collected between August 2013 and November 2013 from patients’ pharmacy refill data. Usage of aspirin, tienopiridine, statin, angiotensin converting enzyme inhibitor, beta blocker (BB), warfarin, angiotensinogen receptor blocker, nitrate, trimetazidine, calcium channel blocker, and diuretic were recorded.

Results: Usage rates of angiotensinogen receptor blocker, trimetazidine, calcium channel blocker, warfarin, diuretic, and fibrate were not statistically different between patients with CAD and normal CAG. Rates of using aspirin (50.3% vs. 39.1%, p=0.005), tienopiridine (25.6% vs. 9.8%, p<0.001), angiotensin converting enzyme inhibitor (38.0% vs. 21.7%, p<0.001), statin (48.5% vs. 30.6%, p<0.001), BB (56.8% vs. 40.2%, p<0.001) and nitrate (15.1% vs. 6.0%, p<0.001) were higher in patients with CAD. Rate of patients using all four drugs, antiplatelet agent, statin, angiotensin converting enzyme inhibitor, and BB was only 13.1% in CAD group. Only 25.8% of patients with CAD used all three of antiplatelet agent, statin, and BB.

Conclusion: Patients with CAD are not on optimal medical treatment. These patients should be questioned in every visit in terms of the status of their treatment to administer the optimum medications to reduce cardiovascular mortality and morbidity.

Keywords : Coronary angiography; coronary artery disease; medication adherence
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