ISSN : 1301-5680
e-ISSN : 2149-8156
TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
Serum prolidase activity, total oxidant/antioxidant, and nitric oxide levels in patients with esophageal squamous cell carcinoma
Fuat Sayır1, Abidin Şehitoğulları2, Halit Demir3, Mehmet Aslan4, Ufuk Çobanoğlu1, Cahit Bilgin5
1Department of Thoracic Surgery, Van Yüzüncü Yıl University Faculty of Medicine, Van, Turkey
2Department of Thoracic Surgery, Sakarya University Faculty of Medicine, Sakarya, Turkey
3Department of Chemistry, Van Yüzüncü Yıl University Faculty of Science, Van, Turkey
4Department of Internal Medicine, Van Yüzüncü Yıl University Faculty of Medicine, Van, Turkey
5Department of Chest Diseases, Sakarya University Faculty of Medicine, Sakarya, Turkey
DOI : 10.5606/tgkdc.dergisi.2019.16888
Background: This study aims to assess the prolidase activity, nitric oxide levels, and oxidative status in patients with esophageal squamous cell carcinoma.

Methods: The study included 30 patients with esophageal squamous cell carcinoma (11 males, 19 females; mean age 61±3 years; range, 28 to 77 years) and 30 healthy controls (10 males, 20 females; mean age 58±5 years; range, 31 to 73 years). Serum prolidase activity, total antioxidant capacity, total oxidant status, and nitric oxide levels were measured. In addition, the oxidative stress index was calculated.

Results: Prominently elevated serum prolidase activity, oxidative stress index values, total oxidant status, and nitric oxide levels were detected in the patient group (p<0.05). Lower total antioxidant capacity levels were observed in the patient group (p<0.05).

Conclusion: Increased oxidant status with increased nitric oxide levels and prolidase activity were found in esophageal squamous cell carcinoma patients. Impairment of antioxidant mechanism with increased prolidase activity and nitric oxide levels may have a crucial role in the etiopathogenesis of esophageal squamous cell carcinoma.

Keywords : Esophageal cancer, nitric oxide, prolidase, total antioxidant capacity, total oxidant status
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