Castleman’s disease is a rare lymphoproliferative disorder, which usually occurs in the chest. The localized form, which is the most common, is often asymptomatic, but can cause nonspecific thoracic symptoms such as cough and dyspnea. Surgical removal is the choice of approach for the management of such cases, in both confirming the diagnosis and curative treatment. A 43-year-old woman who had a history of dry cough for the last six months and a 24-year-old man who had a right anterior chest pain complaint for a year were admitted to our clinic. Thorax computed tomography of cases showed a right hilar well-defined intraparenchymal lesion in the former one and a mass lesion located on the right anterior chest wall in the latter. Surgical intervention was planned in both cases. Histopathological examination of the surgical specimen of both cases revealed hyaline vascular type Castleman’s disease. We report two unusual thoracic manifestations of Castleman’s disease with chest wall and intraparenchymal location, the latter of which is extremely rare.

Keywords : Castleman’s disease; intraparenchymal; surgical excision