ISSN : 1301-5680
e-ISSN : 2149-8156
TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
Pretreatment with carnosol in lung ischemia reperfusion-induced renal injury
Burhan Apilioğulları1, Recep Keşli2, Hıdır Esme3, Ali Yüceaktaş4, Banu Yoldaş3
Department of Thoracic Surgery, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
1Department of Thoracic Surgery, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
2Departments of Medical Microbiology, Konya Training and Research Hospital, Konya, Turkey
3Departments of Thoracic Surgery Konya Training and Research Hospital, Konya, Turkey
4Departments of Anesthesiology and Reanimation, Konya Training and Research Hospital, Konya, Turkey
DOI : 10.5606/tgkdc.dergisi.2014.9362
Background: This experimental study aims to investigate the protective effects of carnosol on kidney injury induced by lung ischemia/reperfusion (I/R).

Methods: Twenty-four New Zealand white rabbits were randomized into three groups. Group IR; lung I/R group (60 min ischemia-60 min reperfusion), group CIR; bolus injection of carnosol before lung I/R, and group S; sham group (pulmonary hilum was not clamped). Renal tissue myeloperoxidase (MPO) and intercellular adhesion molecule-1 (ICAM-1) levels were evaluated.

Results: Renal tissue MPO and ICAM-1 levels were significantly higher in the group IR compared to the group CIR and group S (p=0.021 and p=0.0001 respectively). No statistically significant difference in the parameters evaluated was detected between the group CIR and the group S.

Conclusion: Our study result suggests that lung I/R injury causes increased renal tissue MPO and ICAM-1 levels, which are related to activated neutrophil sequestration and carnosol may play a protective role against this kidney injury.

Keywords : Carnosol; ischemia reperfusion; lung; renal injury
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