Moxifloxacin dependent torsades de pointes in a bradycardic patient with multiple risk factors

doi:10.5606/tgkdc.dergisi.2015.10138

Fatih Ada, Mehmet Taşar, Cahit Sarıcaoğlu, Mustafa Bahadır İnan, Adnan Uysalel

Department of Cardiovascular Surgery, Medical Faculty of Ankara University, Ankara, Turkey

DOI : 10.5606/tgkdc.dergisi.2015.10138

Torsades de pointes (TdP), which is associated with a prolonged QT interval, is a rare but potentially fatal arrhythmia. The most common cause of drug-induced QT prolongation is inhibition of the rapidly activating component of the delayed rectifier potassium current. Rapidly activating component of the delayed rectifier potassium current inhibition delays repolarization by blocking the potassium in myocytes. In this article, we present a patient who had TdP risk factors including female sex, organic cardiac disease, and bradycardia. On the fifth day of 400 mg/day oral moxifloxacin administration, the patient had an episode of TdP, which progressed to ventricular fibrillation, and was successfully defibrillated.

Keywords : Cardiac surgery; moxifloxacin; torsades de pointes

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