THE COMPARISON OF SENSITIVITY OF BLOOD VOLUME DETERMINATION METHODS WITH RADIOACTIVE Cr51 METHOD

Nurgül Yurtseven, *Fevzi Toraman, **Ömer Fehmi Yardı, ***Mehmet Kaplan, Vedat Özkul, ***Abdullah Kemal Tuygun, Sevim Canik

Siyami Ersek Göğüs Kalp Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Anestezi ve Reanimasyon Kliniği, İstanbul
*Acıbadem Hastanesi, Anestezi Kliniği, İstanbul
**Siyami Ersek Göğüs Kalp Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Nükleer Tıp Uzmanı, İstanbul
***Siyami Ersek Göğüs Kalp Damar Cerrahisi Eğitim ve Araştırma Hastanesi, Kalp Damar Cerrahisi Kliniği, İstanbul

Background: It is important to know the patient's blood volume in order to determine the amount and composition of priming solution and to minimize the undesired effect of excessive hemodilution arised during aortocoronary bypass grafting. Among the methods being used radioactive Crom 51 (Cr51) labeled eritrocyte method is the most sensitive method for determination of blood volume. In this study, blood volume of patients who were undergoing coronary bypass graft operation was determined by three different methods and Cr51 method was compared with others.

Methods: Twenty patients (16 men, mean age 56.7 ± 7.8 years) were included in the study. Blood volume was calculated by using four different techniques for each patient. These methods were Cr51, dilution, weight-height-gender, and weight alone in Group 1, 2, 3 and 4, respectively.

Results: Avarage blood volumes were 4628 ± 978 mL, 3756 ± 1294 mL, 4903 ± 671 mL and 5536 ± 826 mL in Groups 1, 2, 3 and 4, respectively. Blood volume in Group 2 was significantly lower (p < 0.05). There was no difference between Group 1 and G roup 3, Group 4 (p > 0.05).

Conclusions: This study demonstrated that the sensivity of dilution method is significantly lower. In the method using only weight, there was a 1000 mL difference which could be significant in certain clinical conditions although it did not show statistical significance. Our observations demonstrate that in patients undergoing coronary bypass graft, determination of blood volume by using weight-height-gender would be more suitable.

Keywords : Blood volume, coronary bypass, Crom 51, hemodilution

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