ISSN : 1301-5680
e-ISSN : 2149-8156
TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
The risk factors associated with postoperative mediastinitis in cardiac surgery: a systematic review and meta-analysis
Selen Öztürk1, İbrahim Öztürk2, Seher İlhan3
1Department of Cardiovascular Surgery, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
2Department of Anaesthesiology and Reanimation, Göztepe Training and Research Hospital, İstanbul, Turkey
3Department of Anaesthesiology and Reanimation, Medical Faculty of Uludağ University, Bursa, Turkey
DOI : 10.5606/tgkdc.dergisi.2015.10754
Background: In this review, we aimed to analyze the risk factors of mediastinitis after open cardiac surgery.

Methods: The literature screening was performed at Pubmed, Ovid, and Sciencedirect databases without date limitation. Studies investigating the co-existing diseases were included. The results of trials were evaluated with random or fixed effect model according to the heterogeneity.

Results: A total of 5009 articles were attained after database searching. Thirty five articles were included to the metaanalysis including 131.158 patients who met inclusion criteria. The most possible preoperative risk factors for mediastinitis were atrial fibrillation, pulmonary disease, diabetes mellitus, renal disease, peripheral vascular disease and systemic hypertension (p<0.05). Pulmonary hypertension, malignancy, hepatic and neurological diseases, heart failure and dyslipidemia were not found to be risk factors (p>0.05). Heterogeneity was not observed for four (renal, hepatic, neurological and peripheral vascular diseases) of 12 factors (I2<25%).

Conclusion: The results of our meta-analysis showed that preoperative co-existing diseases such as pulmonary hypertension, malignancy, heart failure, hepatic and neurological diseases, and dyslipidemia may not be risk factors for the development of mediastinitis following cardiac surgery.

Keywords : Cardiac surgery; mediastinitis; risk factor
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