Alterations in bronchial nitric oxide release and pulmonary function after cardiopulmonary bypass in patients with normal and decreased respiratory capacity

Şahin Şenay; Gökçen Orhan; Ayliz Velioğlu; Batuhan Özay; Murat Sargın; Müge Taşdemir; Okan Yücel; Erol Kurç; Serap Aykut Aka

Şahin Şenay¹, Gökçen Orhan¹, Ayliz Velioğlu², Batuhan Özay¹, Murat Sargın¹, Müge Taşdemir¹, Okan Yücel¹, Erol Kurç¹, Serap Aykut Aka¹

¹Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, İstanbul
²Department of Public Health, Medicine Faculty of Marmara University, İstanbul

Background: The aim of this study is to evaluate the pulmonary function and define the alterations in bronchial nitric oxide (NO) release in correlation with the vascular endothelial NO release in patients with normal and decreased respiratory capacity undergoing coronary artery bypass graft surgery under cardiopulmonary bypass.

Methods: Twenty patients with normal pulmonary functions and 20 patients with decreased respiratory function were involved in the study. Endotracheal aspiration samples and plasma samples were obtained just after the entubation, at the end of the cardiopulmonary bypass and at the postoperative sixth hour. The respiratory functional status, bronchial NO release and vascular NO release were evaluated.

Results: The NO levels in plasma and bronchial samples, and respiratory capacity were gradually decreased; and respiratory index values significantly deteriorated in both groups.

Conclusion: These findings show that patients with chronic obstructive lung disease undergoing cardiopulmonary bypass have similar lung damage with patients who have normal respiratory capacity.

Keywords : Cardiopulmonary bypass; coronary artery bypass; lung volume measurements; nitric oxide

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