ISSN : 1301-5680
e-ISSN : 2149-8156
TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
Intraaortic Catalase Administration to Prevent Spinal Cord Ischemia-Reperfusion Injury
Gökhan İPEK, Ergun DEMİRSOY, Harun ARBATLI, Mehmet BALKANAY, Vakur OLGAÇ, Mesut ŞİŞMANOĞLU, Ömer IŞIK, Cevat YAKUT
Koşuyolu Kalp ve Araştırma Hastanesi, İstanbul Üniversitesi Onkoloji Enstitüsü Onkolojik Patoloji Bilim Dalı, İstanbul

The effects of intraaortic catalase infusion to prevent spinal cord ischemia-reperfusion injury was investigated in this experimental study. White New Zealand rabbits while New Zealand rabbits were used, whose primary source of blood supply to he spinal cord is the infrarenal used, whose primary source of blood supply is infrarenal aorta. Aorta was clamped below the left renal vein and above the iliac bifurcation for 30 minutes in 8 control rabbits (group I) without any protective measures. Adjunctive intraaortic catalase 10.000 U/kg was given just before aortic occlusion and after releasing the clamp in the experimental group (group II; n=8). Spinal cord function was assessed 24 and 48 hours after the operation occording to Tarlov scale. Seven of the animals in t he control group had complete lower extremity paraplegia (grade 0). One animal had slight joint movements (grade 1). No complete paraplegia was observed in the experimental group. Three animals were in grade 4, four animals were in grade 3, and one animal was in grade 2 neurological status. Animals were sacrified and spinal cords were harvested after 48 hours for histologic examination In conslusion, the administration of intraaortic catalase reduced the neurologic injury secondary to spinal cord ischmeia in the rabbit model.

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