ISSN : 1301-5680
e-ISSN : 2149-8156
TURKISH JOURNAL OF
THORACIC AND
CARDIOVASCULAR SURGERY
Turkish Journal of Thoracic and Cardiovascular Surgery     
Effects of Prophylactic Tranexamic Acid and Desmopressin Use on Blood Loss and Blood Product Transfusion After Cardiac Operations
Ömer ÇAKIR, Ahmet KORUKÇU, Hakan GERÇEKOĞLU, Hasan KARABULUT, Mahmut AKYILDIZ, Hüseyin SOYDEMİR, Ece DUMAN, İsmail AĞAR, Besim YİĞİTER
Prof. Dr. Siyami Ersek Göğüs ve Kalp Damar Cerrahisi Merkezi
In open heart surgery negative effect of cardiopulmonary bypass on coagulation system increases postoperative bleeding. Tranexamic acid and desmopressin were used in order to eliminate fibrinolyzis and platelet disfunction arising as a result of that negative effect of CPB. 40 patients undergoing elective coronary artery bypass operations were studied, one group of 20 patients (group I) given tranexamic acid (10 mg/kg infusion over 20 minute followed by an infusion of l mg/kg for 10 hours) and desmopressin (0.3 mg/kg infusion over 20 minute) and one subsequent group of 20 patients (group II) serving as a control group. All patients were treated by the same team and the groups comparable in all major clinical parameters. The mean mediastinal drainage in group I was 501.5±106 ml versus in group II 778.0±157 ml. Patients in the placebo group received more fresh-frozen plasma. We conclude that prophylactic tranexamic acid and desmopressin can be administered safely to decrease postoperative bleeding and possibly decrease the frequency of blood product transfusion.
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