The Comparison of the Inotropic Effects of Levosimendan and Amrinone After Ischemia in Isolated Perfused Guinea Pig Hearts

SÜZER Öner, BOZKURT A. Kürşat, SÜZER Asuman, AYKAÇ Zuhal, BARLAS Aydın

Cerrahpaşa Tıp Fakültesi Farmakoloji ve Göğüs Kalp Damar Cerrahisi Anabilim Dalları, Siyami Ersek Göğüs Kalp Damar Cerrahisi Merkezi, İstanbul

Levosimendan is a new phosphodiesterase-inhibitör inotropic agent with calcium-sensitizing properties. This study was planned to find its dose dependent cardiovascular effects in normal and postischemic conditions in comparison with amrinone. Guinea pig hearts were perfused with Krebs-Henseleit solution in Langendorff apparatus. Cardiac contractility, ECG were recorded and coronary flow measurements were made. Levosimendan or amrinone were applied from different columns in rising concentrations before and after cardioplegic arrest.

Levosimendan and amrinone did not change coranary flow and heart rate significantly at any concentration (p>0.05). Both groups had worse contractility in reperfusion period. Levosimendan was a more potent inotropic agent in the reperfusion period because this group had higher +dx/dtmax (p=0.004) values. Contractility was also better in levosimendan but this was not statistically significant (p=0.359). In conclusion, levosimendan is a betten inotropic drug for ischaemic hearts than amrinone and this may be due to its calcium sensitizing properties in addition to the phosphodiesterase inhibiting activity.

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