ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Comparison of the NT-proBNP levels between coronary artery bypass grafting patients and concomitant coronary artery bypass grafting with valve replacement patients
Hanife Karakaya Kabukçu1, Sibel Şimşek1, Nursel Şahin1, Tülin Aydoğdu Titiz1, Sebahat Özdem2, Atalay Mete3
1Department of Anesthesiology and Reanimation, Medicine Faculty of Akdeniz University, Antalya
2Department of Biochemistry, Medicine Faculty of Akdeniz University, Antalya
3Department of Cardiovascular Surgery, Medicine Faculty of Akdeniz University, Antalya
Background: In this article, we examined the relationship between the pre- and postoperative brain natriuretic peptide (BNP) levels and pre-, intra-, and postoperative hemodynamic parameters in patients undergoing coronary artery bypass grafting (CABG) and combined CABG and valve operations.

Methods: Thirty patients with II and III ASA enrolled in the study were divided into two groups, each with 15 patients: CABG surgery (Group 1, 13 males, 2 females; mean age 62.2±8.6 years) and CABG + valve replacement surgery (Group 2, 13 males, 2 females; mean age 64.1±10.6 years). Patient data were prospectively collected. Anesthetic induction and endotracheal intubation were performed with 10 μg/kg fentanyl and 0.1-0.2 mg/kg etomidate, and 0.15 mg/kg cisatracurium. Isoflurane 1%, cisatracurium 0.1 mg/kg/hr infusion and 0.15 μg/kg/min fentanyl was used for anesthetic maintenance. Systemic and pulmonary arterial pressures were monitored. NT-proBNP levels and troponin T and CK-MB levels were recorded at pre- and postoperative 4th and 12th hours in both groups.

Results: Demographic and hemodynamic data were not significantly different between the two groups. In both groups, NT-proBNP values increased to peak levels at 24 hours postoperatively, however it was not associated with hemodynamic parameters and inotropic support.

Conclusion: There was no statistical difference between NT-proBNP levels in both groups preoperatively. Postoperative NT-proBNP levels were higher in group 2 (longer cross-clamp, and cardiopulmonary bypass time) at the 4th and 12th hours. However the duration in hospital and in the intensive care unit were longer in group 1 patients with high preoperative NT pro-BNP levels.

Keywords : Brain natriuretic peptide; coronary artery bypass grafting; endocrine system
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