ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Use of xenograft conduits in congenital heart disease
Bülent Sarıtaş, Süleyman Özkan, Salih Özçobanoğlu, Murat Özkan, Sait Aşlamacı
Başkent Üniversitesi Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Ankara
DOI : 10.5606/tgkdc.dergisi.2011.083
Background: We aimed to evaluate our nine years of experience with xenograft conduits in which we constructed continuity between the pulmonic ventricle and pulmonary artery and to determine the risk factors for reoperations.

Methods: One hundred and seventy-six patients who underwent open heart surgery with xenograft conduits between January 2000 and January 2009 were evaluated retrospectively. Overall, 215 conduits were used (in the first operations and reoperations). Shellhigh conduits were used in 74 patients, Contegra in 53, Cryolife in 42, Aortech in 35, Tissumed in eight, and other types of conduits were used in three patients. After discharge, all patients were evaluated by transthoracic echocardiography at regular six-month intervals. Twelvederivation electrocardiograms were obtained from all patients during the control visits. Cardiac catheterization was performed when transthoracic echocardiography demonstrated significant conduit stenosis or regurgitation.

Results: Early hospital mortality was 17% (n=30). These patients died due to low cardiac output (n=9), bleeding (n=4), arrhythmia (n=7), cerebrovascular accident (n=3), infection (n=4), and other reasons (n=3). These patients were operated on due to truncus arteriosus (n=19), transposition of great arteries (n=5), tetralogy of Fallot (n=2), pulmonary atresia (n=2), and double outlet right ventricle (n=2). The mean followup time was 78±21 months. Thirty-nine (22.1%) patients were reoperated on due to conduit failure. The interval between the first operation and reoperation was 43±28 months. This interval was the shortest with the Cryolife and Tissumed conduits and longest with the Contegra and Shellhigh ones. Reoperation was performed frequently in patients with transposition of great arteries, ventricular septal defect, and pulmonary atresia.

Conclusion: Xenograft transplantation is important in congenital heart disease, but the reoperation requirement is the most important disadvantage. Although there is no statistical significance, early operation age and use of porcine conduit are the risk factors for reoperation.

Keywords : Congenital heart disease; reoperation; xenotransplantation
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