ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Identification of the concentration of iodopovidone pleurodesis in rats for the maximal effectiveness
Rasih Yazkan1, Berkant Özpolat2, Levent Duman3, Sema Bircan4, Kemal Kürşat Bozkurt4, Sedat Güneş1
1Department of Thoracic Surgery, Süleyman Demirel University School of Medicine, Isparta, Turkey
2Department of Thoracic Surgery, Kırıkkale University School of Medicine, Kırıkkale, Turkey
3Department of Pediatric Surgery, Süleyman Demirel University School of Medicine, Isparta, Turkey
4Department of Pathology, Süleyman Demirel University School of Medicine, Isparta, Turkey
DOI : 10.5606/tgkdc.dergisi.2013.7696
Background: This study aims to investigate the efficacy and safety of different doses of iodopovidone for pleurodesis and to evaluate the histopathological changes in thyroid tissue.

Methods: Thirty-eight male Albino Wistar rats (260-320 g, 6-8 months old) included in this experimental study were randomly divided into four groups. Groups 1, 2, and 3 were given 2 mL/kg intrapleural iodopovidone at concentrations of 1%, 2%, 4%, respectively, while group 4 was administered intrapleural saline. The surfaces were graded by macroscopic and microscopic examination on Day 30 and thyroid tissues were histopathologically examined.

Results: Iodopovidone at concentrations of 2% and 4% resulted in significantly more adhesions and inflammatory response. Four percent iodopovidone produced nonsignificant microscopic changes in the contralateral visceral pleural surface. No vacuolization in thyroid tissue showing hyperthyroidism was observed in the groups.

Conclusion: We suggest that 2% iodopovidone is enough for an effective and safe pleurodesis and the concentration of iodopovidone may be raised to 4% in unsuccessful cases. However, as the study was conducted on rats, it still remains to be elucidated that the similar results can be achieved in human studies.

Keywords : Iodine; iodopovidone; pleurodesis; thyroid
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