ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effect of genetic polymorphisms on the mechanical heart valve dysfunction
Ali İhsan Parlar1, Seyhan Babaroğlu1, Ahmet Tulga Ulus1, Ufuk Tütün1, Müge Mısırlıoğlu2, Mustafa Seren1, Ferit Çiçekcioğlu1, Salih Fehmi Katırcıoğlu1
1Department of Cardiovascular Surgery, Türkiye Yüksek İhtisas Training and Research Hospital, Ankara, Turkey
2Metis Biotechnology Ltd, Ankara, Turkey
DOI : 10.5606/tgkdc.dergisi.2013.7816
Background: This study aims to investigate genetic polymorphisms in patients with mechanical heart valve dysfunction.

Methods: Between January 1994 and December 2004, a total of 83 patients including 18 patients who were reoperated due to mechanical heart valve dysfunction (group 1), 15 patients with normal functions with lower international normalized ratio (INR) levels who underwent mechanical valve replacement (group 2), and 50 healthy individuals (group 3) were included. Factor V Leiden, prothrombin, interleukin (IL-6), and tumor necrosis factor alpha (TNF-a) polymorphisms were investigated for possible relationships between these factors and mechanical heart valve dysfunction.

Results: A significant difference in IL-6 polymorphism was found between group 1 and group 3 (p<0.05). Other polymorphisms were not significantly associated with mechanical heart valve dysfunction among the groups. The IL-6 G-174C polymorphism was found to be significantly associated with mechanical heart valve dysfunction.

Conclusion: Interleukin-6, the key inflammatory response cytokine, may play an effective role in mechanical heart valve dysfunction possibly through ongoing chronic inflammatory processes.

Keywords : Genetic polymorphism; interleukin; mechanical heart valve dysfunction
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