Role of vitamin D binding protein (VDBP) gene polymorphisms in lung cancer

Onur Baykara; Ezel Erşen; Şebnem Batur; Nur Buyru

doi:10.5606/tgkdc.dergisi.2017.13292

Onur Baykara¹, Ezel Erşen², Şebnem Batur³, Nur Buyru¹

¹İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye
²İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye
³İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye

DOI : 10.5606/tgkdc.dergisi.2017.13292

Background: This study aims to investigate the role of different alleles of GC gene in the etiology of lung cancer.

Methods: The study included 77 patients with lung cancer (73 males, 4 females; mean age 59.6±9.2 years; range 21 to 72 years) and 25 healthy individuals (21 males, 4 females; mean age 47.3±5.4 years; range 23 to 61 years). Polymorphisms in vitamin D binding protein gene of all participants were examined by polymerase chain reaction-restriction fragment length polymorphism method.

Results: Of the patients, the genotype 1S-2 was found in 32.4%, 1F-1S in 28.6%, 1S-1S in 28.6%, 1F-2 in 7.8% and 1F-1F in 2.6%, while the genotype frequencies in control group were 28%, 24%, 36%, 4% and 8%, respectively (p=0.35).

Conclusion: We did not detect any relationship between vitamin D binding protein gene polymorphisms and lung cancer.

Keywords : Lung cancer; polymorphism; vitamin D binding protein

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