ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Role of vitamin D binding protein (VDBP) gene polymorphisms in lung cancer
Onur Baykara1, Ezel Erşen2, Şebnem Batur3, Nur Buyru1
1İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı, İstanbul, Türkiye
2İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı, İstanbul, Türkiye
3İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul, Türkiye
DOI : 10.5606/tgkdc.dergisi.2017.13292
Background: This study aims to investigate the role of different alleles of GC gene in the etiology of lung cancer.

Methods: The study included 77 patients with lung cancer (73 males, 4 females; mean age 59.6±9.2 years; range 21 to 72 years) and 25 healthy individuals (21 males, 4 females; mean age 47.3±5.4 years; range 23 to 61 years). Polymorphisms in vitamin D binding protein gene of all participants were examined by polymerase chain reaction-restriction fragment length polymorphism method.

Results: Of the patients, the genotype 1S-2 was found in 32.4%, 1F-1S in 28.6%, 1S-1S in 28.6%, 1F-2 in 7.8% and 1F-1F in 2.6%, while the genotype frequencies in control group were 28%, 24%, 36%, 4% and 8%, respectively (p=0.35).

Conclusion: We did not detect any relationship between vitamin D binding protein gene polymorphisms and lung cancer.

Keywords : Lung cancer; polymorphism; vitamin D binding protein
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