ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Does tumor volume affect survival in patients with operated early-stage non-small-cell lung cancer?
Şeyda Örs Kaya1, Tevfik İlker Akçam2, Onur Akçay3, Özgür Samancılar1, Kenan Can Ceylan1, Ozan Usluer1
1Department of Thoracic Surgery, Dr. Suat Seren Chest Diseases and Thoracic Surgery Training and Research Hospital, Izmir, Turkey
2Department of Thoracic Surgery, Medical Faculty of Ege University, Izmir, Turkey
3Department of Thoracic Surgery, Karsıyaka State Hospital, Izmir, Turkey
DOI : 10.5606/tgkdc.dergisi.2017.13520
Background: This study aims to investigate whether tumor volume affects survival in patients with operated early-stage nonsmall- cell lung cancer.

Methods: A retrospective analysis of 156 patients (146 males, 10 females; mean age 62.3±8.0 years; range 38 to 79 years) with non-small-cell lung cancer who underwent anatomical resection and mediastinal lymph node dissection between September 2009 and June 2013 was performed. The tumor volumes were calculated using histopathological data. The effect of tumor volume on prognosis and survival was investigated.

Results: Of the patients, 116 had Stage I disease and 40 patients had Stage II disease. The mean tumor volume was 38.2±54.6 (range, 356.15 to 0.01) cm3, and the mean largest diameter was 4.2±2.0 (range, 10 to 0.3) cm. In the Cox regression analysis, the tumor volume below the cut-off value (29.69 cm3) increased survival with an odds ratio (OR) of 2, and this value was statistically significant (p=0.022). The cut-off value per T factor was 4.5 cm and the OR was 1.7; however, no significant correlation with the survival was observed (p=0.058).

Conclusion: The present study found a closer correlation between the tumor volume and survival in contrast to the known correlation between the tumor’s largest diameter and survival. Based on our study results, it is recommended to calculate and consider the tumor volume along with the tumor diameter in the staging of lung cancer.

Keywords : Lung cancer; prognosis; staging; tumor volume
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