ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The comparison of pleurodesis effects of iodopovidone at different concentrations and magnesium silicate: An experimental study
Ekin Zorlu1, Salih Kür2, Zeynep Pekcan3, Pınar Atasoy4, Nesimi Günal2, Koray Dural2, Berkant Özpolat2
1Department of Thoracic Surgery, University of Health Sciences, Izmir Bozyaka Training and Research Hospital, Izmir, Turkey
2Department of Thoracic Surgery, Kırıkkale University Faculty of Medicine, Kırıkkale, Turkey
3Department of Surgery, Kırıkkale University Faculty of Veterinary Medicine, Kırıkkale, Turkey
4Department of Pathology, Koç University Faculty of Medicine, Istanbul, Turkey
DOI : 10.5606/tgkdc.dergisi.2021.20664
Background: This experimental study aims to investigate the pleurodesis effects of iodopovidone at different concentrations (2% and 4%) and sterile talc in a rat model.

Methods: Forty male Wistar Albino rats were randomly divided into four equal groups including 10 rats in each group. Groups 1, 2, and 3 were designed as the study, and Group 4 as the control group. In Group 1, 4 g sterile talc was given in the slurry form at 20 mL 0.9% saline solution, in Group 2 and Group 3 10% iodopovidone solution were given at 4% and 2% concentrations, respectively, and in Group 4, 0.9% saline was only administrated as 3 mL into the pleural space. All rats were sacrificed on Day 30 and evaluated for macroscopic and microscopic examination. Microscopic evaluation was performed for alveolar collapse, alveolar hemorrhage, alveolar infiltration and fibrosis. Brain, liver, and kidney tissues were also examined.

Results: Iodopovidone macroscopically caused a significant adhesion similar to sterile talc at a concentration of 4%. The pleurodesis effect of iodopovidone at a concentration of 4% was significantly similar to talc, when microscopic parameters were evaluated. Granulomas due to sterile talc were observed in the opposite hemithorax. Brain, liver, and kidney examinations revealed no systemic distribution for both agents.

Conclusion: Iodopovidone is a powerful alternative to sterile talc with its easy accessibility and low cost. In this study, 4% iodopovidone was found to provide effective and safe pleurodesis in rats. We believe that the use of this concentration in clinical studies would provide more effective results.

Keywords : Chemical pleurodesis, iodopovidone, malignant pleural effusion, sterile talc
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