ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The Effect of Extracorporeal Circulation and Various Priming Solutions On Hemostasis
Yahya ÜNLÜ, Azman ATEŞ, Hikmet KOÇAK, Münacettin CEVİZ, Necip BECİT, *Salim TEKİN, **Sevinç KUŞKAY
Atatürk Üniversitesi Tıp Fakültesi, ERZURUM, Kalp Damar Cerrahisi Anabilim Dalı
*İç Hastalıkları (Hematoloji) Anabilim Dalı
**Biokimya Anabilim Dalı
The effects of cardiopulmonary bypass (CPB) and various priming solutions on hemostasis were investigated in 28 patients undergoing CPB for coronary bypass surgery.

Twenty eight patients were randomly choosen and divided into four groups. in group-I (n= 7), isotonic solution (IS) as control group, in group-II (n= 7), 20% human albumin (HA), in group-III (n= 7), low molecular weight hydroxyethyl starch (HES) solution (10% HES; mean molecular weight 200.000 Da, molar substitution 0.5), and in group-IV (n= 7), haemaccel (H) solution were used as priming solutions. Plasma levels of prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen, protein-S, protein-C and tissue-plasminogen activator (t-PA) were determined before induction of anesthesia, 3 min. after starting of CPB, after opening the aortic clamp, after termination of CPB, 1, h after the operation, and 24. h after the operation. And also amount of postoperative drainage were measured for all patients.

Results of cases in each group were compared cases in aech group and the other groups. All patients in each group were similar with respect to age, associated medical problems, extent of coronary arter disease, total pump time, and aortic croosclamp time, number of grafts per patient and level of hypothermia.

There was statistically significant difference between before induction of anesthesia and during KPB (p<0.001). There were significant increase in PT (p<0.01), PTT and t-PA (p<0.05)and signifıcant decrease in fibrinogen, protein-S and protein-C (p<0.05), during CPB. HA and HES at priming decreased sıgnificantly the amount of postoperative drainage according to other priming solutions (p<0.05).

HA and HES have less effects on coagulations factors and using them in priming solution decrease amount of postoperative drainage in patients undergoing CPB for coronary bypass surgery.

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