THE PROTECTIVE ROLE OF PENTOXIFYLLINE IN THE PERIPHERAL SYSTEM DURING EXTRACORPOREAL CIRCULATION

Haşim ÜSTÜNSOY, Cumhur SİVRİKOZ, Metin TOPAL, * Feza NURÖZLER, ** Oya KÖYLÜOĞLU, ** Binnur ERBAĞCI, *** Hasan KOÇOĞLU

Gaziantep Üniversitesi Tıp Fakültesi Göğüs Kalp Damar Cerrahi Anabilim Dalı, GAZİANTEP
^*Department of Cardiothoracic Surgery, College of Physicians and Surgeons of Columbia University New York USA
^**Gaziantep Üniversitesi Tıp Fakültesi Biyokimya Anabilim Dalı, GAZİANTEP
^***Gaziantep Üniversitesi Tıp Fakültesi Anestezioloji ve Reanimasyon Anabilim Dalı, GAZİANTEP

Pentoxifilin inhibits 5nucleotidase, so that it decreases losing of ATP. Therefore Ptx may avoid cell damage that occurs after ischemic period during open heart surgery. In this study, the patients who have got different diagnosis (ASD, VSD, coronary disease, and valve disease), and were operated with open heart technique were divided into two subgroups which were study group (n = 25) and control group (n = 10). We added Ptx (500 mg/lt) in the prime solution in the study group. Tumor necrosis factor alpha (TNF-a), interleukin-6 (IL-6), Interleukin-8 (IL-8) were studied in the blood that was sampled from right atrium before and after extracorporeal circulation in the both groups. Alanin aminotransferaz, aspartate aminotransferaz, blood urea nitrogen, creatinine, bilirubin, alchalen phosphotase, lactic dehidrogenase, creatine phosphokinase were also studied. We also compared preoperatively and postoperatively hemodinamic data, daily drenage, coagulation-bleeding time in the both groups.

We used nonparametric Wicoxon test to evaluate the results. Results of TNF-a, IL-6, IL-8 were meaningful statistically (p < 0.005). The other parameters also expressive (p < 0.05). There was no difference in hemodynamic data, daily drenage, coagulation-bleeding time between both groups.

We suggest that PTX has got the important protecting role on the peripheral organs during extracorporeal circulation.

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