Effect of Aprotinin on Need for Blood Transfusion in Coronary

Atalay METE, Cengiz TÜRKAY, Tülin AYDOĞDU, Ömer BAYEZİD

Akdeniz Üniversitesi Tıp Fakültesi, Kalp-Damar Cerrahisi ve Anesteziyoloji ABD - Antalya

The effect of Aprotinin was evaluated in two groups of patients undergoing cardiopul- monary bypass. in a prospective placebo controlled study, 29 patients having primary aorto- coronary bypass grafting received aprotinin (560 mg) and 29 patients placebo, during the operative procedure. Standardized anesthetic, perfusion and surgical techniques were used.

Blood loss was reduced from 325.0±33.1 ml to 175.8+16.2 ml; p<0.0005 (mean ± standart error of the mean) with Aprotinin therapy. And the need for blood transfusion was reduced from 4.3±0.4 U. to 2.4+0.2 U; p<0.0001 (mean ± standart error of the mean). The protease inhibitor, aprotinin therapy reduced postoperative blood loss and therefore the routine application of aprotinin during coronary artery surgery is to be recommended.

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