Nontraumatic muscular hematoma of lower extremity in a patient using warfarin and its relationship with VKORC1, CYP2C9 gene polymorphism

Sadık Volkan Emren; Nihan Kahya Eren; Serhan Özyıldırım; Hale Bülbül; Sadettin Uslu

doi:10.5606/tgkdc.dergisi.2015.10141

Sadık Volkan Emren¹, Nihan Kahya Eren¹, Serhan Özyıldırım¹, Hale Bülbül², Sadettin Uslu²

¹Katip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, Kardiyoloji Kliniği, İzmir, Türkiye
²Katip Çelebi Üniversitesi Atatürk Eğitim ve Araştırma Hastanesi, Dahiliye Kliniği, İzmir, Türkiye

DOI : 10.5606/tgkdc.dergisi.2015.10141

Warfarin is the most frequently used oral anticoagulant agent today. Warfarin response can be affected by environmental factors such as dietary habits and drugs as well as genetic factors, and this might increase bleeding risk. In this article, we report a 79-year-old male patient who developed nontraumatic hematoma of left lower extremity despite using low-dose warfarin, and whose genetic analyses revealed CYP2C9*2*3, VKORC1 AA and VKORC1 TT gene polymorphisms.

Keywords : Bleeding; gene polymorphism; warfarin

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