Background: The purpose of this study was to evaluate the short-term (30 days) hematological, biochemical, and end-organ effects of the Levitronix CentriMag® left ventricular assist system (LVAS) in a bovine model.

Methods: Three calves underwent Levitronix CentriMag® LVAS implantation without the use of cardiopulmonary bypass. The pump was operated with a fixed flow rate of 5 L/min. Data related to pump function and hemodynamics were collected continuously at 1-hour intervals until study termination. Hematologic and biochemical (liver and kidney function) tests were performed preoperatively (baseline) and daily throughout the study period. Histopathologic examination of the end-organs (brain, heart, liver, kidney, spleen, and lungs) was performed after the study termination.

Results: The planned date of termination (30 days) was reached in all the animals without complication and device failure. The pumps, inflow and outflow cannulae were free of thrombus. Hematological tests were within normal limits during the study period. Elevations observed in the levels of white blood cell count, and decreases in hematocrit, hemoglobin, and red blood cell count were of short duration; these parameters returned to normal within one week of surgery. Creatine kinase and serum glutamic oxaloacetic transaminase levels showed transient increases within the first three days of surgery. Other biochemical parameters were within normal limits. Postmortem examination of the explanted organs revealed no evidence for ischemia or infarction.

Conclusion: Hematological, biochemical, and end-organ functions were not adversely affected by short-term Levitronix CentriMag® LVAS support.

Keywords : Blood circulation; cattle; heart failure, congestive/therapy; heart-assist devices; prosthesis design; prosthesis implantation/methods