ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effects of preoperative chemotherapy and beta glucan on bronchial anastomosis in rabbits: a preliminary study
Bayram Altuntaş1, Sami Ceran2, Güven Sunam3, Mustafa Gültekin4, Hasan Esen5
1Department of Thoracic Surgery, Medical Faculty of Atatürk University, Erzurum, Turkey
2Departments of Thoracic Surgery, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
3Department of Thoracic Surgery, Medical Faculty of Selçuk University, Konya, Turkey
4Department of Thoracic Surgery, Beyhekim State Hospital, Konya, Turkey
5Departments of Pathology, Necmettin Erbakan University, Meram Medical Faculty, Konya, Turkey
DOI : 10.5606/tgkdc.dergisi.2015.11722
Background: This study aims to investigate the effects of an immunostimulant, beta glucan, on the bronchial anastomosis in rabbits that received chemotherapy in preoperative period.

Methods: Forty-five New Zealand male rabbits were used in this study. The rabbits were divided into three groups as group 1 (control), group 2 (chemotherapy), and group 3 (chemotherapy + beta glucan) with 15 rabbits in each group. The left main bronchus was incised completely and then endto- end anastomosis was performed in all groups. Cisplatin was administered on the preoperative first day and etoposide was administered on the preoperative first, second, and third days in group 2. In group 3, in addition to the same chemotherapy protocol, 10 mg/kg/day beta glucan was administered via enteral route starting from seven days before operation until one day before sacrifications. The rabbits were sacrificed at postoperative third, fifth, and seventh days by groups of five. The bronchial anastomosis lines were removed and tissue sections were stained with hematoxylin and eosin.

Results: In pathological analysis, while there were statistically significant differences between group 1 and group 2 and between group 2 and group 3, there was no difference between group 1 and group 3 in terms of bronchial healing.

Conclusion: The use of beta glucan during chemotherapy treatment may improve bronchial healing at postoperative period.

Keywords : Bronchus; cancer; chemotherapy; sleeve lobectomy
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