ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effect of the presence of autocrine motility factor receptor on survival in patients with stage I epidermoid lung cancer
Kamil Kaynak1, Berrak Akgöz 1, Ahmet Demirkaya 1, Ezel Erşen 1, Murat Kara2, Büge Öz3
1İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Göğüs Cerrahisi Anabilim Dalı,İstanbul
2Kırıkkale Üniversitesi Tıp Fakültesi Göğüs Cerrahisi Anabilim Dalı, Kırıkkale
3İstanbul Üniversitesi Cerrahpaşa Tıp Fakültesi, Patoloji Anabilim Dalı, İstanbul
Background: We aimed to investigate the existence of autocrine motility factor receptor (AMFR) and its effect on survival in patients with stage I squamous cell carcinoma.

Methods: The study included 30 patients (23 males, 7 females; mean age 60±10 years; range 33 to 77 years) with stage I squamous cell carcinoma of the lung. None of the patients received chemotherapy or radiotherapy before or after surgery. The mean follow-up period was 48±11 months. The chi-square test was used for comparison of variables. The cumulative survival rates were calculated by the Kaplan-Meier method and the significance was assessed by the log-rank test. The effects of AMFR and clinical factors on survival were assessed by univariate and multivariate analyses using Cox’s proportional hazard model.

Results: Six tumors (20%) showed positive staining for AMFR. The overall survival in patients with AMFR expression was significantly worse than those without AMFR expression (p=0.052). Multivariate analysis showed AMFR expression (p<0.016) and older age (p<0.015) as independent prognostic factors on poor survival.

Conclusion: Expression of AMFR can be a useful marker for the follow-up of patients with cancer and for metastatic potential of tumors. However, further studies are required to determine its value for adjuvant therapy.

Keywords : Motility factor receptor; carcinoma, squamous cell; lung neoplasms/metabolism; survival analysis; tumor markers, biological
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