The relationship between deep venous thrombosis and undiagnosed malignant disease

Oral Hastaoğlu; Onur Sokullu; Soner Sanioğlu; Şahin Şenay; Koray Akkan; Recep Er; Fuat Bilgen

Oral Hastaoğlu¹, Onur Sokullu², Soner Sanioğlu², Şahin Şenay³, Koray Akkan¹, Recep Er¹, Fuat Bilgen²

¹ Gümüşhane Devlet Hastanesi Kalp ve Damar Cerrahisi Kliniği, Gümüşhane
² Dr. Siyami Ersek Göğüs Kalp ve Damar Cerrahisi Eğitim ve Araştırma Hastanesi Kalp ve Damar Cerrahisi Kliniği, İstanbul
³ Acıbadem Kadıköy Hastanesi Kalp ve Damar Cerrahisi Bölümü, İstanbul

Background: We investigated the relationship between deep venous thrombosis and undiagnosed malignant disease.

Methods: Forty-five consecutive patients (22 males, 23 females; mean age 59±18 years; range 19 to 83 years) in whom a diagnosis of deep venous thrombosis was made within a year were prospectively evaluated with respect to undiagnosed malignant disease. Evaluations included physical examination, routine laboratory tests, and abdominopelvic ultrasonography.

Results: Undiagnosed malignancy was detected in three patients (6.6%), namely, stomach, bladder, and lung cancers. Eighteen patients and 27 patients had idiopathic and secondary deep venous thrombosis, respectively. Malignant disease was found in two patients (11.1%) in the idiopathic group, and in one patient (3.7%) in the secondary group.

Conclusion: An undiagnosed malignancy may be the underlying cause of deep venous thrombosis, particularly in idiopathic cases. Early diagnosis of a malignant disease would be beneficial to the patients and the healthcare centers.

Keywords : Neoplasms, unknown primary/diagnosis; venous thrombosis/ complications

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