ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Chemokine receptor 5 Δ32 gene polymorphism and abdominal aortic aneurysms
Murat Aydın1, Nurkay Katrancıoğlu1, Şinasi Manduz1, Erhan Atahan1, Oğuz Karahan1, Öztürk Özdemir2, Öcal Berkan1
1Cumhuriyet Üniversitesi Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Sivas
2Cumhuriyet Üniversitesi Tıp Fakültesi, Tıbbi Genetik Anabilim Dalı, Sivas
Background: In this study, we aimed to investigate the relationship between abdominal aortic aneurysm (AAA) and chemokine receptor 5 Δ32 (CCR5) gene polymorphism as a risk factor.

Methods: Fifty-eight patients (41 males, 17 females; mean age 62.9±6.5 years; range 45 to 78 years) operated on our clinic between May 2008 and March 2009 with the diagnosis of AAA, and 58 healthy volunteers (38 males, 20 females; mean age 58.8±11.6 years; range 30 to 79 years) with normal aortic diameters measured by computed tomography were included in this study. Thirty-two base p deletions in the CCR5 gene were screened after obtaining genomic DNAs from peripheral blood samples of the patients.

Results: When the groups were compared with the predisposing risk factors for the development of AAA, no significant difference was observed (p>0.05). Eleven patients (19.0%) had heterozygote CCR5 gene mutation in the AAA group, however, only one patient (1.7%) had heterozygote CCR5 gene mutation in the control group. While the CCR5 homozygote was normal in 47 (81.0%) patients, the CCR5 homozygote was normal in 57 (98.3%) volunteers in the control group. Chemokine receptor 5 Δ32 heterozygote gene mutation was significantly higher in the AAA group. (p=0.004).

Conclusion: Consequently, a relationship between CCR5 gene polymorphism and AAA was demonstrated in this study. We think that hereditary factors considered between unchanged etiologic factors play a role in the development of AAA and we believe that AAA can be treated before serious complications occur with frequent clinical check ups in people with hereditary predisposition.

Keywords : Abdominal aortic aneurysm; CCR5; chemokine; gene polymorphism; 32 base p deletion
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