ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Associations between common 3435 C>T variants of the multi-drug resistance [MDR-1 (ABCB1)] gene and abdominal aortic aneurysm: a pilot study
Şinasi Manduz1, Nurkay Katrancıoğlu1, Oğuz Karahan1, Mehmet Birhan Yılmaz2, Öztürk Özdemir3, Öcal Berkan1
1Departments of Cardiovascular Surgery, Medicine Faculty of Cumhuriyet University, Sivas
2Departments of Cardiology, Medicine Faculty of Cumhuriyet University, Sivas
3Departments of Medical Genetics, Medicine Faculty of Cumhuriyet University, Sivas
DOI : 10.5606/tgkdc.dergisi.2011.008
Background: The aim of the study was to reveal the effect of the C3435T MDR-1 gene polymorphism in AAA, which has been postulated to play a role in the inflammatory process and protection against oxidative stress.

Methods: In this study, we scanned the MDR gene polymorphisms in peripheral blood samples of the 58 patients (41 males, 17 females; mean age 62.9±6.6 years) whom were operated on after the diagnosis of AAA, and of the 58 healthy individuals (38 males, 20 females; mean age 58.8±11.6 years) have normally measured aorta diameters on abdominal computed tomography scan.

Results: We found that MDR-1 C3435T gene CT variant (x2= 5.80; p=0.016) and MDR-1 C3435T gene TT variant (x2=11.47; p=0.001) polymorphisms was statistically significant in AAA cases (p<0.05). The demographic findings were similar in each group.

Conclusion: These obtained preliminary results suggest that the T allele polymorphism of the MDR-1 gene is associated with AAA. We belive that such molecular studies will blaze a trail for future studies on the understanding of AAA etiology.

Keywords : Abdominal aortic aneurysm; inflammation; MDR-1 gene polymorphism; reverse hybridization
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