Effect of cardiopulmonary bypass on acetyl salicylic acid resistance in patients undergoing isolated elective coronary artery bypass graft surgery

doi:10.5606/tgkdc.dergisi.2013.7292

Emre Boysan, Ertekin Utku Ünal, Kerem Yay, Haşmet Bardakçı, Cemal Levent Birincioğlu

Türkiye Yüksek İhtisas Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye

DOI : 10.5606/tgkdc.dergisi.2013.7292

Background: This study aims to investigate the effects of cardiopulmonary bypass (CPB) on acetyl salicylic acid resistance after coronary artery bypass graft (CABG) surgery.

Methods: Forty consecutive patients who underwent isolated elective CABG surgery in cardiovascular surgery department were prospectively enrolled in this study. The patients were divided into two groups according to the use of CPB as on-pump group (n=20) and off-pump group (n=20).

Results: Fourteen of twenty patients in the on-pump group had acetyl salicylic acid resistance, whereas only five of twenty patients in the off-pump group had acetyl salicylic acid resistance. Statistical analyses revealed that the use of CPB increased the risk of acetyl salicylic acid resistance by 46.8 fold.

Conclusion: The risk of acetyl salicylic acid resistance increases in patients who undergo CABG surgery using CPB, compared to those who do not undergo surgery without CPB. Lack of sufficient standardization of the tests for acetyl salicylic acid resistance and high costs lead to this phenomenon which is underestimated among the medical community.

Keywords : Acetylsalicylic acid; cardiopulmonary bypass; coronary artery bypass graft surgery; drug resistance

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