ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effect of Bacille Calmette-Guerin on the immunopathogenesis of tuberculous pleurisy
Tayfun Çalışkan1, Esin Aktaş Çetin2, Oğuzhan Okutan1, Faruk Çiftçi1, Günnur Deniz2, Hatice Kaya3, Zafer Kartaloğlu1
1Department of Pulmonary Diseases, GATA Haydarpaşa Training Hospital, İstanbul, Turkey
2Department of Immunology, Institute of Experimental Medicine (DETAE), İstanbul University, İstanbul, Turkey
3Department of Pulmonary Diseases, Gulhane Military Medical Academy, Ankara, Turkey
DOI : 10.5606/tgkdc.dergisi.2013.7104
Background: This study aims to investigate the role of CD4+ a nd CD8+ T cells and T helper (Th)1/Th2 lymphocyte cell balance in the immunopathogenesis of tuberculous pleurisy and the immunomodulation resulting from Bacille Calmette-Guerin (BCG) were investigated.

Methods: A total of 26 patients, who were pathologically diagnosed as tuberculous pleurisy, including 10 of whom had no BCG vaccine and 16 of whom had BCG vaccine, were included. Total CD3+, CD4+, CD8+ T cells, total CD19+ B cells and natural killer cell ratio as well as intracellular interferon-gamma (IFN-γ), interleukin (IL)-2, IL-4, IL-5 and IL-10 expression in pleural fluid lymphocytes were analyzed.

Results: In BCG positive group, CD8+ T lymphocytes were significantly increased. Intracellular IL-4 levels of lymphocytes in pleural fluid were significantly reduced in these subjects, compared to BCG negative subjects.

Conclusion: BCG vaccine may suppress Th2 type immune response and also lead to increased levels of CD8+ T cells. CD8+ T cells may play an important role in the immunopathogenesis of tuberculous pleurisy.

Keywords : Bacille Calmette Guerin; immunopathogenesis; tuberculous pleurisy
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