Recurrent transfusion-related acute lung injury after open heart surgery: a case report

Tolga Baş,

doi:10.5606/tgkdc.dergisi.2013.5531

Tolga Baş¹, Barış Malbora², Murat Çapanoğlu³, Onur Işık¹, Ali Kutsal¹

¹Dr. Sami Ulus Kadın Doğum, Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi, Kalp ve Damar Cerrahisi Kliniği, Ankara, Türkiye
²Dr. Sami Ulus Kadın Doğum, Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi, Çocuk Hematolojisi Kliniği, Ankara, Türkiye
³Dr. Sami Ulus Kadın Doğum, Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi, Çocuk Sağlığı ve Hastalıkları Kliniği, Ankara, Türkiye

DOI : 10.5606/tgkdc.dergisi.2013.5531

Transfusion-related acute lung injury (TRALI) is a rare clinical syndrome. The risk of a patient having more than one attack is very low. Clinical findings are dyspnea, hypoxemia, hypotension, bilateral pulmonary edema and fever. Granulocyte antibodies, human leukocyte antigen-1 (HLA)-1, HLA-2 antibodies and biologically active lipids like lysophosphatidylcholine in donor plasma are known to play a role in the pathophysiology of the disease. Triggering factors include sepsis, cytokine administration, recent history of surgery and massive blood transfusion. In this article, we report a case of 1.5-year-old girl operated due to congenital heart disease with frequent blood product transfusions and having TRALI attacks for four times, who recovered after cessation of blood product transfusions and supportive therapy.

Keywords : Cardiac surgery; child; recurrent transfusion-related acute lung injury; transfusion reaction; treatment

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