ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effects of dexmedetomidine infusion on renal functions after coronary artery bypass graft surgery: a randomized, double-blind, placebo-controlled study
Deniz Göksedef1, Ozan Onur Balkanay1, Suat Nail Ömeroğlu1, Zeki Talas2, Berk Arapi1, Yerik Junusbekov1, Nevzat Cem Sayılgan3, Gökhan İpek1
1Department of Cardiovascular Surgery, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, Turkey
2Department of Cardiovascular Surgery, Sivas Numune Hospital, Sivas, Turkey
3Department of Anesthesiology and Reanimation, İstanbul University, Cerrahpaşa School of Medicine, İstanbul, Turkey
DOI : 10.5606/tgkdc.dergisi.2013.7645
Background: This study aims to investigate possible effects of dexmedetomidine on renal functions following coronary artery bypass graft (CABG) surgery.

Methods: Between August 2008 and May 2009, consecutive 100 patients who underwent CABG surgery in our clinic were included in this double-blind and placebo-controlled study. Patients were randomized to either dexmedetomidine infusion or placebo. The sedation level of the patients was regulated using Ramsey Sedation Scale. Permuted blocks of four method was used to randomize patients.

Results: A total of 86 patients were included in the analysis including 49 in the dexmedetomidine group and 37 in the placebo group. There was no statistically significant difference in major intraoperative and postoperative variables between the groups. Postoperative day 1 creatinine clearances values above cut-off point of 110 μg/day were significantly different between the groups. These changes were not observed in postoperative fifth day creatinine clearances values.

Conclusion: Low dose dexmedetomidine has no major effect on urine output and renal indices such as urea, creatinine and creatinine clearances. However, it may have a positive effect on renal functions when total dose is uptitrated, particularly.

Keywords : Coronary artery bypass graft surgery; dexmedetomidine; renal function
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