The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting

Ümit Menteşe; Orhan Veli Doğan; Süheyla Doğan; İbrahim Turan; Sefer Usta; Mine Demirbaş; Ahmet Çağrı Aykan; Aşkın Kılıç; Selim Demir; Süleyman Caner Karahan

doi:10.5606/tgkdc.dergisi.2015.10641

Ümit Menteşe¹, Orhan Veli Doğan², Süheyla Doğan³, İbrahim Turan⁴, Sefer Usta¹, Mine Demirbaş¹, Ahmet Çağrı Aykan⁵, Aşkın Kılıç¹, Selim Demir⁶, Süleyman Caner Karahan⁶

¹Departments of Cardiovascular Surgery, Training and Research Hospital, Trabzon, Turkey
²Department of Cardiovascular Surgery, Medical Faculty of Sakarya University, Sakarya, Turkey
³Department of Cardiovascular Surgery, Ankara High Specialty Training and Research Hospital, Ankara, Turkey
⁴Department of Genetic and Bioengineering, Engineering and Natural Sciences Faculty of Gümüşhane University, Gümüşhane, Turkey
⁵Departments of Cardiology, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Trabzon, Turkey
⁶Department of Medical Biochemistry, Medical Faculty of Karadeniz Technical University, Trabzon, Turkey

DOI : 10.5606/tgkdc.dergisi.2015.10641

Background: This study aims to evaluate the potential of ischemia-modified albumin (IMA) to predict the myocardial infarction in on pump coronary artery bypass grafting (ONCABG) patients.

Methods: Fifty elective isolated ONCABG patients (41 males, 9 females; mean age 66 years; range 56 to 75 years) were included in the study. Patients were divided into perioperative myocardial infarction (PMI; n=8) and non-infarction (NPMI; n=42) groups according to perioperative cardiac troponin I (cTnI) values and ECG findings. Serum IMA levels were measured preoperatively, 20 minutes after aortic cross clamping, 30 minutes, at 3, 6, 12 and 24 hours after declamping.

Results: Compared to the NPMI group, the declamping 30 minutes, 3, 6 and 12 hours IMA levels were higher in the PMI group (p=0.002, p=0.048, p=0.023, p=0.007, respectively). In both NPMI and PMI groups, the 20 minutes after aortic cross clamping IMA levels were higher compared to the preoperative IMA levels (p=0.0001, p=0.038, respectively).

Conclusion: Our study results show that IMA may be an early marker of myocardial infarction in the ONCABG patients.

Keywords : Coronary artery bypass grafting; ischemia-modified albumin; perioperative myocardial infarction

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