ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The relationship between ischemia-modified albumin and myocardial infarction in on-pump coronary artery bypass grafting
Ümit Menteşe1, Orhan Veli Doğan2, Süheyla Doğan3, İbrahim Turan4, Sefer Usta1, Mine Demirbaş1, Ahmet Çağrı Aykan5, Aşkın Kılıç1, Selim Demir6, Süleyman Caner Karahan6
1Departments of Cardiovascular Surgery, Training and Research Hospital, Trabzon, Turkey
2Department of Cardiovascular Surgery, Medical Faculty of Sakarya University, Sakarya, Turkey
3Department of Cardiovascular Surgery, Ankara High Specialty Training and Research Hospital, Ankara, Turkey
4Department of Genetic and Bioengineering, Engineering and Natural Sciences Faculty of Gümüşhane University, Gümüşhane, Turkey
5Departments of Cardiology, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital, Trabzon, Turkey
6Department of Medical Biochemistry, Medical Faculty of Karadeniz Technical University, Trabzon, Turkey
DOI : 10.5606/tgkdc.dergisi.2015.10641
Background: This study aims to evaluate the potential of ischemia-modified albumin (IMA) to predict the myocardial infarction in on pump coronary artery bypass grafting (ONCABG) patients.

Methods: Fifty elective isolated ONCABG patients (41 males, 9 females; mean age 66 years; range 56 to 75 years) were included in the study. Patients were divided into perioperative myocardial infarction (PMI; n=8) and non-infarction (NPMI; n=42) groups according to perioperative cardiac troponin I (cTnI) values and ECG findings. Serum IMA levels were measured preoperatively, 20 minutes after aortic cross clamping, 30 minutes, at 3, 6, 12 and 24 hours after declamping.

Results: Compared to the NPMI group, the declamping 30 minutes, 3, 6 and 12 hours IMA levels were higher in the PMI group (p=0.002, p=0.048, p=0.023, p=0.007, respectively). In both NPMI and PMI groups, the 20 minutes after aortic cross clamping IMA levels were higher compared to the preoperative IMA levels (p=0.0001, p=0.038, respectively).

Conclusion: Our study results show that IMA may be an early marker of myocardial infarction in the ONCABG patients.

Keywords : Coronary artery bypass grafting; ischemia-modified albumin; perioperative myocardial infarction
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