Methods: The data of 53 patients (30 boys, 23 girls; median age 6.5 years; range 3 to 19 years) who were performed transcatheter closure of VSD between September 2006 and April 2013 in a single center were retrospectively analyzed. Perimembranous (n=42) and muscular (n=11) VSDs with hemodynamic significance which were suitable for transcatheter closure were included in the study. Four different devices were used in the study: the perimembranous Amplatzer VSD occluder, muscular Amplatzer VSD occluder, ductal Amplatzer occluder I, and II.

< b>Results: Median body weight was 21.5 kg (range 13 to 87 kg). The ratio of successful closure was 92%. One patient died due to complete atrioventricular block five days after the procedure and one patient died due to cerebral hemorrhage one day after the procedure.

Conclusion: Transcatheter closure of VSDs is an efficient method in selective cases. However, occurrence of complete atrioventricular block is a major concern in this procedure. Surgery should be considered as the first treatment choice in perimembranous VSD. However, in selected patients, transcatheter approach can be used for defect closure when necessary measures are taken against possible complications.