In vitro effects of prostaglandin E1, prostaglandin I2 and papaverine on internal thoracic artery graft

Ganime Mısırlıoğlu; Serhat Hüseyin; Volkan Yüksel; Orkut Güçlü; Hakan Karadağ; Suat Canbaz; Turan Ege; Hasan Sunar

doi:10.5606/tgkdc.dergisi.2015.10990

In vitro effects of prostaglandin E1, prostaglandin I2 and papaverine on internal thoracic artery graft

Ganime Mısırlıoğlu¹, Serhat Hüseyin¹, Volkan Yüksel¹, Orkut Güçlü¹, Hakan Karadağ², Suat Canbaz¹, Turan Ege¹, Hasan Sunar¹

¹Trakya Üniversitesi Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Edirne, Türkiye
²Trakya Üniversitesi Tıp Fakültesi, Farmakoloji Anabilim Dalı, Edirne, Türkiye

DOI : 10.5606/tgkdc.dergisi.2015.10990

Background: This study aims to investigate the effects of prostaglandin E1, prostaglandin I2, and papaverine on internal thoracic artery grafts which are used during coronary artery bypass graft operations.

Methods: Ten patients (9 males, 1 female; mean age 53.7 years; range 46 to 68 years) who were operated in our clinic between March 2013 and September 2013 were enrolled in the study. Dose-dependent effects of prostaglandin E1 and prostaglandin I2 on internal thoracic artery at a concentration interval of 10-9 M-10-2.5 M were observed.

Results: While prostaglandin I2 had stronger relaxation response than prostaglandin E1 on internal thoracic artery graft, papaverine had the strongest relaxation response.

Conclusion: Prostaglandin E1 and prostaglandin I2, which are used in the treatment of many aterosclerotic cardiovascular and peripheral artery diseases, may prevent vasoconstriction in internal thoracic artery grafts. Further clinical studies are required regarding decreasing perioperative mortality and morbidity by increasing graft patency.

Keywords : Coronary artery bypass graft operation; internal thoracic artery; organ bath; papaverine; prostaglandin E1; prostaglandin I2; saphenous vein

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