Lung transplantation for graft-versus-host disease after allogeneic stem cell transplantation: A report of two cases

Erman Bağatur Öztürk

doi:10.5606/tgkdc.dergisi.2020.19009

Erman Bağatur Öztürk¹, Mustafa Vayvada², Atakan Erkılıç³, Ahmet Erdal Taşçı²

¹Department of Thoracic Surgery, University of Health Sciences, Istanbul Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey
²Department of Thoracic Surgery, University of Health Sciences, Kartal Koşuyolu Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey
³Department of Anesthesiology and Reanimation, University of Health Sciences, Kartal Koşuyolu Thoracic and Cardiovascular Surgery Training and Research Hospital, Istanbul, Turkey

DOI : 10.5606/tgkdc.dergisi.2020.19009

Allogeneic peripheral stem cell transplantation is an effective treatment of malignant and non-malignant hematological diseases. However, it is associated with several complications, such as graft-versus-host disease, and also various complications involving different organ systems. Late-onset non-infectious lung complication is one of them. This pathology may also affect the different anatomical regions in the lung as parenchymas, bronchi, or vessels and may manifest with different clinical presentations. Lung transplantation can be an effective treatment in patients with pulmonary complications after allogeneic stem cell transplantation and also in patients who do not respond to treatment adequately and with a limited life expectancy. Herein, we report two rare cases who underwent lung transplantation after allogeneic stem cell transplantation.

Keywords : Allogeneic stem cell transplantation, lung transplantation, non-infectious pulmonary disease

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