ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Prognostic value of troponin/creatinine ratio in patients with chest pain
Hayri Canbaz1, Suat Görmel2
1Department of Emergency Medicine, Yıldırım Beyazıt University, Yenimahalle Training and Research Hospital, Ankara, Türkiye
2Department of Cardiology, Gülhane Training and Research Hospital, Ankara, Türkiye Received: September 30, 202
DOI : 10.5606/tgkdc.dergisi.2023.24249
Background: The aim of this study was to investigate the prognostic value of the troponin/creatinine ratio in patients presenting with chest pain and to identify laboratory values affecting mortality.

Methods: Between October 1st, 2016 and April 30th, 2019, a total of 5,079 patients (2,844 males, 2,235 females; median age: 65 years; range, 49 to 83 years) who presented to the emergency department with chest pain and whose troponin and creatinine measurements were done were retrospectively analyzed. Laboratory data and 28-day mortality rates were evaluated. The patients were divided into two groups according to 28-day mortality rates after the initial emergency department admission as survivors (n=4,793) and non-survivors (n=286).

Results: There were statistically significant differences in the white blood cell count, C-reactive protein, creatinine, high-sensitivity troponin I, and troponin/creatinine ratio between the groups (p<0.05). The high-sensitivity troponin I ?31.96 pg/dL, creatinine ?1.11 mg/dL, C-reactive protein ?43.94 mg/L, and troponin/creatinine ratio ?25.12 were independent predictors of 28-day mortality (p<0.05). A C-reactive protein value of ?43.94 mg/L was found to be more specific (81.14%) than the other markers for mortality.

Conclusion: Troponin/creatinine ratio is a predictor of mortality in patients presenting to the emergency department with chest pain and high-sensitivity troponin I, creatinine, and C-reactive protein seem to be independent risk factors for 28-day mortality.

Keywords : Cardiac, chest pain, creatinine, renal failure, survival, troponin
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