ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
EFFECTS OF IOHEXOL ON PULMONARY FUNCTIONS IN PATIENTS UNDERGOING DIAGNOSTIC CORONARY ANGIOGRAPHY
Ramazan Akdemir, Hakan Özhan, *Öner Balbay, *Mete Erbaş, **Hüseyin Gündüz, *Peri Arbak, Mehmet Yazıcı, Enver Erbilen, Sinan Albayrak, *Ali Nihat Annakaya, **Cihangir Uyan
Abant İzzet Baysal Üniversitesi Düzce Tıp Fakültesi, Kardiyoloji Ana Bilim Dalı, Düzce
*Abant İzzet Baysal Üniversitesi Düzce Tıp Fakültesi, Göğüs Hastalıkları Ana Bilim Dalı, Düzce
**Abant İzzet Baysal Üniversitesi İzzet Baysal Tıp Fakültesi, Kardiyoloji Ana Bilim Dalı, Bolu
Background:Adverse respiratory reactions have been reported with intravascular radiographic contrast media. The aim of the present study was to assess the effects of iohexol on pulmonary functions in patients undergoing diagnostic coronary angiography.

Methods: Thirty patients diagnosed as coronary artery disease undergoing diagnostic coronary angiography were enrolled in the study. Subjects with chronic obstructive pulmonary disease, asthma, allergic bronchitis, myocardial infarction and documented systolic dysfunction by transthoracic echocardiography were excluded. The respiratory functions of the patients before and immediately after the coronary angiography were measured and arterial blood gas analyses were performed. The subjects were divided into two groups according to results of angiography as having coronary artery disease (Group 1) and without significant coronary artery disease (Group 2). The angiography procedures were performed by a single, experienced angiographer. Left Ventriculography was not performed on any patient

Results: The results gathered before and after angiography procedure were compared. Forced expiratory volume in the first second (FEV1), maximum mid-expiratory flow rate, (MMFR) 25-75, arterial oxygen pressure (PaO2) and bicarbonate (HCO3) were significantly reduced ( p < 0.01), where as forced vital capacity (FVC), pH, oxygen saturation and arterial carbondioxide pressure were not changed. The comparison between two groups resulted that FEV1 and PaO2 were significantly decreased after angiography in Group 1.

Conclusions: Diagnostic coronary angiography using iohexol decreases ventilatory functions in a small but significant extent in patients without any overt pulmonary disease. Therefore they should be used cautiously in patients with chronic lung disease.

Keywords : Iohexol, coronary angiography, ventilatory function
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