ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Alterations in bronchial nitric oxide release and pulmonary function after cardiopulmonary bypass in patients with normal and decreased respiratory capacity
Şahin Şenay1, Gökçen Orhan1, Ayliz Velioğlu2, Batuhan Özay1, Murat Sargın1, Müge Taşdemir1, Okan Yücel1, Erol Kurç1, Serap Aykut Aka1
1Department of Cardiovascular Surgery, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Center, İstanbul
2Department of Public Health, Medicine Faculty of Marmara University, İstanbul
Ba­ckgro­und: The aim of this study is to evaluate the pulmonary function and define the alterations in bronchial nitric oxide (NO) release in correlation with the vascular endothelial NO release in patients with normal and decreased respiratory capacity undergoing coronary artery bypass graft surgery under cardiopulmonary bypass.

Metho­ds: Twenty patients with normal pulmonary functions and 20 patients with decreased respiratory function were involved in the study. Endotracheal aspiration samples and plasma samples were obtained just after the entubation, at the end of the cardiopulmonary bypass and at the postoperative sixth hour. The respiratory functional status, bronchial NO release and vascular NO release were evaluated.

Results: The NO levels in plasma and bronchial samples, and respiratory capacity were gradually decreased; and respiratory index values significantly deteriorated in both groups.

Co­nclusio­n: These findings show that patients with chronic obstructive lung disease undergoing cardiopulmonary bypass have similar lung damage with patients who have normal respiratory capacity.

Keywords : Cardiopulmonary bypass; coronary artery bypass; lung volume measurements; nitric oxide
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