ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Venous thromboembolism and inherited thrombophilia
Erhan Atahan1, Erkan Çağlar2, Cihat Şarkış3, Serdal Uğurlu4
1Cumhuriyet Üniversitesi Tıp Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dalı, Sivas
2Göztepe Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, İstanbul
3Cumhuriyet Üniversitesi Tıp Fakültesi, İç Hastalıkları Anabilim Dalı, Gastroenteroloji Bilim Dalı, Sivas
4Fatih Sultan Mehmet Eğitim ve Araştırma Hastanesi, Romatoloji Kliniği, İstanbul
Inherited thrombophilia is a genetic tendency to venous thromboembolism. Coagulation abnormalities are common in the general population and therefore will present spontaneously in some individuals. Patients with a family history of thrombosis are at an increased risk for a mutation. Factor V Leiden and the prothrombin, G20210A mutation the commonest inherited risk factors for thrombosis, are associated with an increased risk of venous thromboembolism. These causes of thrombophilia increase the risk of venous thromboembolism recurrence. Deficiencies in protein C, protein S, and antithrombin-III account for most of the remaining cases of thrombophilia. Inherited thrombophilia should be suspected in patients with one or more of the following clinical features: idiopathic thrombosis, thrombosis at a young age, recurrent thrombosis, and thrombosis at an unusual site. Reliable assays are now available to test for the presence of the various causes of inherited thrombophilia.
Keywords : Antithrombin III; blood coagulation disorders; factor V Leiden; inherited thrombophilia; protein C and S deficiency; venous thromboembolism
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