ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effects of pulsatile flow characteristics on hemolysis, transfusion requirement, and hemostasis in open heart surgeries
Erdem Silistreli1, Baran Uğurlu1, Hüdai Çatalyürek1, Yusuf Kuserli1, Tuğra Gençpınar1, Eyüp Hazan1, Nejat Sarıosmanoğlu2, Ünal Açıkel3
1Department of Cardiovascular Surgery, Medicine Faculty of Dokuz Eylül University, Ankara, Turkey
2Department of Pediatric Cardiovascular Surgery, Department of Pediatric Cardiovascular Surgery,
3Department of Cardiovascular Surgery, Özel Ege Hospital, Denizli, Turkey
DOI : 10.5606/tgkdc.dergisi.2012.044
Background: The aim of this study was to investigate the effects of pulsatile and nonpulsatile perfusion on hemolysis parameters and protection of blood components.

Methods: This randomized, controlled and prospectively designed study included two independent groups, consisting of 27 nonpulsatile (NP) and 24 pulsatile (P) cases who had undergone open heart surgical procedures. Demographic and hemodynamic data were recorded. The effects of perfusion types were evaluated in terms of free hemoglobin (free Hb), haptoglobin (Hp), lactate dehydrogenase (LDH), potassium (K+), platelet number (plt) and urine Hb. These levels were measured in preoperative period, 30 and 60 minutes after initiation of cardiopulmonary bypass (CPB), two and 24 hours postoperatively. Also, total chest drainage and transfusion requirement were assessed.

Results: Demographic and hemodynamic measurements did not differ between the groups. The mean arterial pressure of the NP group was statistically higher at the 30th minute. Free Hb, Hp, LDH and K+ levels did not differ in both groups in all time points. The urine Hb levels were significantly higher in the P group in the 30th minute. There was no difference regarding total chest drainage amounts and number of transfused erythrocyte cell packages.

Conclusion: A clinically nonsignificant hemolytic effect of pulsatile perfusion can be outlined, although it is mentioned only in the urine Hb measurements on the laboratory basis.

Keywords : Cardiopulmonary bypass; hemolysis; pulsatility
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