ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
The effects of pre-emptive pregabalin on post-thoracotomy pain and epidural analgesia
Mehtap Tunç1, Demet Çınar1, Şaziye Şahin1, Hilal Sazak1, Serdal Kenan Köse2
1Atatürk Göğüs Hastalıkları ve Göğüs Cerrahisi Eğitim ve Araştırma Hastanesi, Anesteziyoloji ve Reanimasyon Kliniği, Ankara, Türkiye
2Ankara Üniversitesi Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Ankara, Türkiye
DOI : 10.5606/tgkdc.dergisi.2014.8029
Background: This study aims to investigate the effects of preoperative single oral dose of pregabalin on postoperative pain, analgesic consumption and side effects in patients undergoing thoracotomy and receiving epidural analgesia.

Methods: Between August 2009 and December 2009 40 patients (34 males, 6 females; mean age 49.5±13.8 years; range 18 to 65 years) who were scheduled for elective thoracotomy in our clinic were included in this prospective, randomized, placebocontrolled, single-blind study. The patients were divided into two groups each containing 20 patients. One hour before surgery, group 1 and group 2 received 150 mg oral pregabalin and oral placebo, respectively. Thoracic epidural patient-controlled analgesia (PCA) was administered in all patients for postoperative pain management. Pain scores, epidural opioid consumption and side effects were recorded for postoperative 72 hours. The patients were also assessed with respect to the incidence and severity of chronic postthoracotomy pain, the presence of allodynia-like pain and the limitation of daily life at three and six months.

Results: Pain scores were significantly lower in group 1, compared to group 2 before PCA, at 1, 4, 12, 24, 48 and 72 hours (p<0.05). In group 1, epidural opioid consumption was significantly lower than group 2 between 0 and 24 hours, and between 48 and 72 hours (p<0.05). The incidence and severity of chronic postthoracotomy pain, and the limitation of daily life were statistically significantly lower in group 1 compared to group 2 at three months (p<0.05).

Conclusion: The present study showed that single oral preoperative dose of 150 mg pregabalin, which was used for postthoracotomy pain control, alleviated pain scores and epidural opioid consumption in early period. Pregabalin also reduced the incidence and the severity of chronic postthoracotomy pain at three months.

Keywords : Analgesia; chronic pain; epidural; pain; postoperative; pregabalin; thoracotomy
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