ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
In vitro effects of amiodarone on coronary artery bypass grafts
Okay Güven Karaca1, Turan Ege2, Suat Canbaz2, Özcan Gür3, Çetin Hakan Karadağ4, Ata Niyazi Ecevit1, Mehmet Kalender1
1Department of Cardiovascular Surgery, Konya Training and Research Hospital, Konya, Turkey
2Departments of Cardiovascular Surgery, Medical Faculty of Trakya University, Edirne, Turkey
3Department of Cardiovascular Surgery, Medical Faculty of Namık Kemal University, Tekirdağ, Turkey
4Departments of Pharmacology, Medical Faculty of Trakya University, Edirne, Turkey
DOI : 10.5606/tgkdc.dergisi.2015.9871
Background: This study aims to investigate the effects of amiodarone on the most commonly used grafts, internal thoracic artery (ITA), saphenous vein (SV), and radial artery (RA) in organ bath.

Methods: Twenty patients (16 males, 4 females; mean ages 58.4±9.9 years; range 38 to 80 years) who underwent isolated coronary artery bypass graft (CABG) surgery between May 2008 and October 2008 were included in this study. Internal thoracic artery, saphenous vein, and radial artery grafts were harvested. Specimens were taken to laboratory in +4 ºC Krebs solution. Specimens were suspended in 10 ml organ bath containing Krebs solution.

Results: Amiodarone caused relaxation in all grafts (ITA, RA, SV) between 10-9-10-3,5 M concentration in a dose dependent manner (p<0.01). Maximum relaxation rates (mean) induced by amiodarone were 78.9%, 74.9% and 66.5% for ITA, RA and SV, respectively.

Conclusion: Although we did not evaluate the endotheliumindependent relaxation response in this study, higher rates of relaxation response were observed with ITA grafts comparing to other grafts, and these results were compatible with literature. According to the results of this study, amiodarone-class III antiarrhythmic agent- caused vasodilation in all three grafts in vitro. Vasodilator effect of amiodarone on grafts may help to increase patency rates.

Keywords : Amiodarone; internal thoracic artery; organ bath; radial artery; saphenous vein
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