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10.5606/tgkdc.dergisi.2015.10138
Moxifloxacin dependent torsades de pointes in a bradycardic patient with multiple risk factors
Fatih Ada, Mehmet Taşar, Cahit Sarıcaoğlu, Mustafa Bahadır İnan, Adnan Uysalel
Department of Cardiovascular Surgery, Medical Faculty of Ankara University, Ankara, Turkey
DOI : 10.5606/tgkdc.dergisi.2015.10138
Torsades de pointes (TdP), which is associated with a
prolonged QT interval, is a rare but potentially fatal
arrhythmia. The most common cause of drug-induced
QT prolongation is inhibition of the rapidly activating
component of the delayed rectifier potassium current.
Rapidly activating component of the delayed rectifier
potassium current inhibition delays repolarization by
blocking the potassium in myocytes. In this article, we
present a patient who had TdP risk factors including female
sex, organic cardiac disease, and bradycardia. On the fifth
day of 400 mg/day oral moxifloxacin administration,
the patient had an episode of TdP, which progressed to
ventricular fibrillation, and was successfully defibrillated.
Keywords : Cardiac surgery; moxifloxacin; torsades de pointes
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