ISSN : 1301-5680
e-ISSN : 2149-8156
Turkish Journal of Thoracic and Cardiovascular Surgery     
Adiponectin and leptin polymorphisms in patients with coronary artery disease
Sefa Şenol1, Hayrettin Tekümit2, Murat Kara3, Kürşat Kargün3, Mustafa Yıldız4
1Department of Cardiovascular Surgery, Elazığ Training and Research Hospital, Elazığ, Turkey
2Department of Cardiovascular Surgery, Medical Faculty of Bezmialem Vakıf University, İstanbul, Turkey
3Departments of Genetic Medicine, Medical Faculty of Elazığ University, Elazığ, Turkey
4Departments of Emergency Medicine, Medical Faculty of Elazığ University, Elazığ, Turkey
DOI : 10.5606/tgkdc.dergisi.2015.11169
Background: In this study, adiponectin and leptin gene polymorphism were analyzed in patients with planned coronary artery bypass graft (CABG) surgeries.

Methods: Between January 2012 and April 2013, 110 patients in the study group (78 males, 32 females; mean age 61.3±7.8 years; range 47 to 76 years) were scheduled for CABG surgery for coronary artery disease (CAD) and 96 healthy subjects without CAD in the control group (68 males, 28 females; mean age 59.4±8.3 years; range 46 to 78 years) were included in the study.

Results: Adiponectin rs2241766 gene polymorphism and allele frequency were statistically significantly lower in the study group (p<0.05). Leptin receptor rs1137101 gene polymorphism and allele frequency were statistically significantly higher in the study group, compared to the controls (p<0.05). The rs7799039 gene polymorphism of leptin was statistically significantly higher in the control group (p<0.05), while there was no statistically significant difference in the allele frequency between the groups (p>0.05). Gene polymorphisms of adiponectin at rs1501299 and their allele frequencies were similar between the study and the control groups (p>0.05).

Conclusion: Our study results showed that gene polymorphism of adiponectin at rs2241766 decreased the risk of CAD, while gene polymorphism of leptin receptor rs1137101 and rs7799039 increased the risk. By demonstrating the biochemical consequences of adiponectin and leptin polymorphisms, this study may, together with larger and more comprehensive studies, serve as a reference concerning these risks associated with these polymorphisms and the benefits of prophylaxis in CAD.

Keywords : Adiponectin; coronary artery disease; leptin; polymorphism
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