GATA Haydarpaşa Eğitim Hastanesi, Göğüs Hastalıkları Kliniği, İstanbul, Türkiye
Middle lobe syndrome is a clinical entity characterized
by chronic or recurrent atelectasis of the right middle
lung lobe. Pathophysiologically, there are two forms of
middle lobe syndrome, namely obstructive and nonobstructive.
Obstructive middle lobe syndrome is usually
caused by endobronchial lesions or extrinsic compression
of the middle lobe bronchus. In the non-obstructive type,
no obstruction of the middle lobe bronchus is evident
during bronchoscopy or with computed tomography
of the thorax. Patients with non-obstructive middle
lobe syndrome usually respond to medical therapy
with bronchodilators, mucolytic agents, and antibiotics.
Surgical resection is indicated for bronchiectasis or
failure of intensive medical therapy to resolve the
atelectasis. Lobectomy is an efficient and safe therapy
modality in these patients.